Thyrotropin Receptor Antibody, Serum (TSH Receptor Antibody / Thyrotropin-binding Inhibitory Immunoglobulin (TBII))

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Category:

Turnaround Time: 1 - 3 days
CPT Code:

83520

Test Type: 0.8 mL Serum
Reference Range:

0.0-1.75 units/L

Overview:

Diagnosis of hyperthyroidism and Graves' disease.

Thyrotropin-receptor antibody is an autoantibody to the thyroid cell receptor for thyroid-stimulating hormone. It can be demonstrated in 90% of patients with Graves' disease, and is the cause of the hyperthyroidism of that condition. The characterization of TRA resolved much confusion about long-acting thyroid stimulator (LATS) and LATS protector, which are both, in fact, thyroid-stimulating autoantibodies which simply behaved differently in animal test systems. These antibodies are present in 50% of euthyroid Graves' disease as well as hyperthyroid patients. They play a major role in the pathogenesis of Graves' disease. Detection of these antibodies is useful in prediction of neonatal hyperthyroidism and prediction of relapse of hyperthyroidism.

Colvin RB, Bhan AK, McCluskey RT, eds. Diagnostic Immunopathology. New York, NY: Raven Press;1988.

Gupta MK. Recent advances in laboratory tests for autoantibodies to thyrotropin receptor protein in Graves' disease. Clin Lab Med. 1988 Jun; 8(2):303-323 (review). PubMed 3284698

Gupta MK. Thyrotropin receptor antibodies: Advances and importance of detection techniques in thyroid disease. Clin Biochem. 1992 Jun; 25(3):193-199. PubMed 1633635

McKenzie JM, Zakarija M. Clinical review 3: The clinical use of thyrotropin receptor antibody measurements. J Clin Endocrinol Metab. 1989 Dec; 69(6):1093-1096. PubMed 2685006

Morris JC 3rd, Hay ID, Nelson RE, Jiang NS. Clinical utility of thyrotropin-receptor antibody assays: Comparison of radioreceptor and bioassay methods. Mayo Clin Proc. 1988 Jul; 63(7):707-717. PubMed 2898572

Nakamura RM, Binder WL. Current concepts and diagnostic evaluation of autoimmune disease. Arch Pathol Lab Med. 1988 Sep; 112(9):869-877 (review). PubMed 3046557

Collection Details:

Collection Instructions:

This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.

Red-top tube or gel-barrier tube.

If tube other than a gel-barrier tube is used, transfer separated serum to a plastic transport tube.

Refrigerate; stable for three days. Stable frozen for one month.