Thyroid Stimulating Hormone (TSH) (1005)

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Category:

CPT Code:

84443

Test Type: 1.0 mL Serum Kit Based
Stability Time:

Stability

Refrigerated: 14 days

Reference Range:
  • Low:  <0.27 µlU/mL
  • Optimal: 0.27-4.20 µlU/mL
  • High:  >4.20 µlU/mL

Overview:

TSH is a peptide hormone synthesized and secreted by the anterior pituitary gland. TSH regulates thyroid gland function.

Methodology

Immunoassay

 

  • TSH is used in the differential diagnosis of primary, secondary, & tertiary hypothyroidism.1-3
  • Is also useful in screening for hyperthyroidism.1-3
  • Allows adjustment of thyroid replacement in hypothyroid patients.1-3
  • High doses of biotin (> 5 mg/day) may interfere with assay results. Patient assumed to be refraining from biotin supplementation for at least 3 days prior to blood draw.

References:

  1. Goodman N, Cobin RH. Reproductive disorders. In: Camacho PM, Gharib H, Sizemore GW, eds. Evidence-Based Endocrinology. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins. 2012:190-228.
  2. Castro MR, Gharib H. Thyroid disorders. In: Camacho PM, Gharib H, Sizemore GW, eds. Evidence-Based Endocrinology. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins. 2012:43-80.
  3. Garber JR, Cobin RH, Gharib H, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocr Pract. 2012;18(6):988-1028.
 

Collection Details:

Collection Instructions:

Preferred Specimen

1.0 mL serum (0.5 mL minimum) collected in serum separator tube (SST/Tiger Top)

Transport Temperature

Refrigerated (ship on frozen cold packs)

Stability

Refrigerated: 14 days