T-Cell Activation Profile, CD8 Subsets

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Category:

Turnaround Time: 1 - 3 days
CPT Code:

86359, 86360, 86356(3)

Test Type: Fill tube(s) to capacity, whole blood
Stability Time:

Temperature

Period

Room temperature

2 days

Refrigerated

Unstable

Frozen

Unstable

Freeze/thaw cycles

Unstable
Reference Range:

Adult Reference Intervals for Lymphocyte Immunophenotyping

 

CD

95% Confidence Interval

Percentage

Cells/mm3

Minimum

Maximum

Minimum

Maximum

CD3+

57.5

86.2

622

2402

CD3+CD4+

30.8

58.5

359

1519

CD3+CD8+

12.0

35.5

109

897

CD3+CD25+

4.9

25.9

79

535

T4:T8 ratio

0.92

3.72

    

CD8+CD38+

0

17.7

0

381

CD8+HLA-DR+

0

4.9

0

117

Overview:

Expanded profile for AIDS monitoring and prognosis. An increase in activation markers is associated with poor prognosis.

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).

Landay AL, Jessop C, Lennette ET, Levy JA. Chronic fatigue syndrome: Clinical condition associated with immune activation. Lancet. 1991 Sep 21; 338(8769):707-712. PubMed 1679864

Sadler D, Keren DF. Surface marker assays in immunodeficiency diseases. In: Keren DF, Hanson CA, Hurtubise PE, eds. Flow Cytometry and Clinical Diseases. Chicago, Ill: ASCP Press;1994:chap 9.

Collection Details:

Collection Instructions:

Lavender-top (EDTA) tube and yellow-top (ACD-A) or (ACD-B) tube.

Invert tube 8 to 10 times immediately after collection. To preserve cellular viability, collect specimen so it will arrive in the laboratory within 48 hours of collection. Indicate date and time of venipuncture on the tube(s) and on the test request form.

Maintain specimen at room temperature.