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Register NowNatural Killer Cell and Activated T-Cell Profile/IL-2r
Create a Free Account to View PricesTurnaround Time: 1 - 3 days
CPT Code: 86357, 86359, 86356
Test Type: Whole blood, fill tube(s) to capacity
Stability Time:
|
Temperature |
Period |
|---|---|
|
Room temperature |
2 days |
|
Refrigerated |
Unstable |
|
Frozen |
Unstable |
|
Freeze/thaw cycles |
Unstable |
Reference Range:
Reference intervals for adults have been established by the laboratory. See table.
Adult Reference Intervals for Lymphocyte Immunophenotyping
|
CD |
95% Confidence Interval |
|||
|---|---|---|---|---|
|
Percentage |
Cells/mm3 |
|||
|
Minimum |
Maximum |
Minimum |
Maximum |
|
|
CD3+ |
58 |
86 |
622 |
2402 |
|
CD3+CD25+ |
5 |
26 |
79 |
535 |
|
CD3-CD56+ |
1 |
19 |
24 |
406 |
Overview:
Assess changes in T-lymphocyte surface markers that may indicate immune stimulation.
This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).
Natural killer (NK) cells are large granular lymphocytes that mediate MHC-unrestricted cytotoxicity against virus-infected and malignant cells and manufacture a number of cytokines following stimulation of the immune system.
The combination of IL-2 and T-cell markers can be used to assess the state of activation of T cells. NK cells are responsible for the destruction of virally infected cells, tumor cells, and antibody-dependent cellular cytotoxicity.
Caligiuri M, Murray C, Buchwald D, et al. Phenotypic and functional deficiency of natural killer cells in patients with chronic fatigue syndrome. J Immunol. 1987 Nov 15; 139(10):3306-3313. PubMed 2824604
Landay AL, Jessop C, Lennette ET, Levy JA. Chronic fatigue syndrome: Clinical condition associated with immune activation. Lancet. 1991 Sep 21; 338(8769):707-712. PubMed 1679864
Lanier L, Jackson A. Monoclonal antibodies: Differentiation antigens expressed on leukocytes. In: Rose N, deMacario E, Fahey J, et al, eds. Manual of Clinical Laboratory Immunology. 4th ed.
Collection Details:
Collection Instructions:
Lavender-top (EDTA) tube and yellow-top (ACD-A) or (ACD-B) tube
Invert tube 8 to 10 times immediately after collection. To preserve cellular viability, collect specimen so it will arrive in the laboratory within 48 hours of collection. Indicate date and time of venipuncture on the tube(s) and on the test request form.
Maintain specimen at room temperature.