Myeloperoxidase (MPO) (604)

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Category:

CPT Code:

83876

Test Type: 1.0 mL EDTA Plasma Kit Based
Stability Time:

Stability

Refrigerated:  4 days

Reference Range:
  • Optimal: <470 pmol/L
  • Borderline: 470-539 pmol/L
  • Increased Risk: ≥540 pmol/L
  • Alert: >1658 pmol/L

Overview:

MPO is an enzyme found in circulating white blood cells (neutrophils) and is also produced by white blood cells (monocytes) in the foam cells within the artery wall. Elevated levels of MPO may indicate the presence of unstable plaque or buildup in the arterial wall and an increased risk of plaque rupture. In patients with high levels of MPO, careful evaluation of CVD risk should be considered by the healthcare professional.

Methodology

Enzyme immunoassay

  • Elevated MPO levels have been shown to be a significant independent risk factor for a major adverse cardiac event (MACE) over the ensuing one to six months.1

References:

  1. Brennan ML, Penn MS, Van Lente F, et al. Prognostic value of myeloperoxidase in patients with chest pain. N Engl J Med. 2003;349(17):1595-1604.

Collection Details:

Collection Instructions:

Preferred Specimen

1.0 mL EDTA plasma collected in plasma separator tube (Pearl Top)

 

Transport Temperature

Refrigerated (ship on frozen cold packs)