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Temperature |
Period |
---|---|
Room temperature |
14 days |
Refrigerated |
14 days |
Frozen |
14 days |
Freeze/thaw cycles |
Stable x3 |
Negative
Overview:
Differential diagnosis of hepatitis; the presence of IgM antibody to hepatitis A virus is good evidence for acute hepatitis A.
Hepatitis A virus is a picornavirus, and antibody is made to capsid proteins. Fecal excretion of HAV peaks before symptoms develop. If hepatitis A antibody is IgM, the hepatitis A infection is probably acute. IgM antibody develops within a week of symptom onset, peaks in three months, and is usually gone after six months. Hepatitis A antibody of IgG type is indicative of old infection, is found in almost 50% of adults, and is not usually clinically relevant. Many cases of hepatitis A are subclinical, particularly in children. Presence of IgG antibody to HAV does not exclude acute hepatitis B or other forms of hepatitis.
Giacoia GP, Kasprisin DO. Transfusion-acquired hepatitis A. South Med J. 1989; 82(11):1357-1360. PubMed 2683125
Lee HS, Vyas GN. Diagnosis of viral hepatitis. Clin Lab Med. 1987; 7(4):741-757 (review). PubMed 3319367
Collection Instructions:
Red-top tube, gel-barrier tube, or lavender-top (EDTA) tube.
If tube other than a gel-barrier tube is used, transfer separated serum or plasma to a plastic transport tube.
Room temperature.
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