Endo+: Melatonin

Overview:

About Endo+
Endo+ offers modular panels for a customizable approach to hormone testing. Select one or multiple panels based on the patient's clinical picture, enjoying cost savings with each addition. 

Endo+ sets the standard for comprehensive hormone evaluations, assessing thyroid, adrenal, melatonin, and sex hormones, along with estrogen metabolism.
Tailor hormonal testing to each patient’s needs with a customizable approach that ensures patients receive exactly what's needed for their unique health situation.
Endo+ reveals the complex interplay of hormones, not just their levels, providing essential insights for informed treatment and patient understanding.

The symphony of hormones deserves its own stage.

Endo+ is the first of its kind in hormonal health, offering the unique ability to test saliva, blood, and urine simultaneously. This flexibility lets providers create tailored hormonal profiles that reveal insights and connections between sex hormones, thyroid function, adrenal health, melatonin rhythms, and estrogen metabolism.

Why Endo+ Stands Out

Unrivaled Comprehensive Evaluation: The most thorough hormone assessment available. 
Modular Testing: Build a personalized profile for each patient
Dynamic Reporting: A synthesized view of hormonal interplay, enhancing patient care.
Cost-Effective Solutions: The more you add, the more you save, making comprehensive care accessible.
Hormones influence each other. Fine-tuning the full hormonal symphony can lead to significant symptom improvement and well-being.

Ideal Candidates for Endo+
Endo+ is suitable for both men and women across various life stages, including cycling, premenopausal, and postmenopausal individuals. It's particularly beneficial for those experiencing symptoms that may be linked to hormonal imbalances, such as:

• Anxiety
• Bowel changes
• Cardiovascular disease
• Changes in hair and skin
• Changes in libido
• Cognitive decline
• Cold sensitivity
• Decreased muscle mass/strength
• Depression
• Fatigue
• Heart palpitations
• Hormone-associated cancers
• Hot flashes and night sweats
• Menstrual irregularities
• Osteoporosis
• Sleep disturbances
• Vaginal dryness
• Weight fluctuations

Medication and Supplement Impact FAQs
Should a patient discontinue a medication or supplement prior to testing?
Genova never recommends that patients discontinue medically necessary medications or supplements in order to complete testing.

There may be times when a patient may stay on a medication or dietary supplement during testing in order to evaluate its effectiveness, especially if a long-term medication. Discontinuing a substance is intended to establish a baseline finding. If you choose to discontinue a medication, a good rule of thumb is to take the biological half-life of the drug times 5 to allow for 'clearance' before testing. With certain medications, the drug itself may have cleared the body, but the effect of the medication may be longer lasting.

How will a medication or supplement impact hormone levels?
In many instances, it is unknown what potential impact a medication or supplement may have on test results.

Any questions regarding a medication or supplement impact on biomarker results can be researched by contacting the manufacturer, pharmacist, and/or searching the literature (PubMed, Google Scholar) for relevant information. Drug databases such as drugs.com, rxlist.com, Epocrates, and pdr.net, or laboratory textbooks such as Fischbach's A Manual of Laboratory and Diagnostic Tests may provide additional information.

What are some known medication interferents?
The medications listed below are direct interferants to hormone assays resulting in falsely low or falsely elevated findings. Testing may not be appropriate for patients who cannot discontinue these medications.

Interfering Medications/ Supplements, Possible Impact on Results

• Biotin – high dose (RDI is 30 mcg) 
• Direct assay interferant for Thyroglobulin Antibody, free T3, free T4, serum DHEA-S, and SHBG.41
  May result in falsely elevated FT3 and FT4 and falsely low levels of TSH.
  The American Thyroid Association recommends holding for at least 2 days prior to testing.42 
• Immunotherapy (i.e., cancer, autoimmune, and other condition treatments)    Immunotherapy or diagnostic procedures utilizing immunoglobulins or immunoglobulin fragments may produce antibodies that interfere with immunoassays. Such interfering antibodies may cause erroneous results. For additional information, visit the section on 'Immunoassay Interferents' below.
• Steroids: Different steroids have differing effects on hormone levels, with some being direct assay interferents.2,3 See Adrenocortex Stress Profile test preparation for more info.
• Fulvestrant: Estrogen receptor antagonist and SERM for advanced breast cancer treatment. Can result in false increases in serum estradiol immunoassay levels.43,44