Deaminated Gliadin Antibodies, IgG

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Category:

Turnaround Time: 1-3 days
CPT Code:

83516

Test Type: 1 mL Serum
Stability Time:

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Overview:

Detection of gliadin antibodies aids in the diagnosis and monitoring of certain gluten-sensitive enteropathies, such as celiac disease and dermatitis herpetiformis.

A negative IgA result in an untreated patient does not rule out gluten-sensitive enteropathies, especially when associated with IgG gliadin antibodies. This can be explained by selective IgA deficiency, a relatively frequent finding in celiac disease. False-positives are possible as other gastrointestinal disorders are known to induce circulating antigliadin antibody, mainly Crohn disease, food protein intolerance, and postinfection malabsorption.

Burgin-Wolff A, Gaze H, Hadziselimovic F, et al. Antigliadin and antiendomysium antibody determination for coeliac disease. Arch Dis Child. 1991 Aug;66(8):941-947. PubMed 1819255

Collin P, Maki M, Keyrilainen O, Hällström O, Reunala T, Pasternack A. Selective IgA deficiency and coeliac disease. Scand J Gastroenterol. 1992 May;27(5):367-371. PubMed 1529270

Kelly CP, Feighery CF, Gallagher RB, Gibney MJ, Weir DG. Mucosal and systemic IgA antigliadin antibody in celiac disease: Contrasting patterns of response in serum, saliva, and intestinal secretion. Dig Dis Sci. 1991 Jun;36(6):743-751. PubMed 2032515

McMillan SA, Haughton DJ, Biggart JD, Edgar JD, Porter KG, McNeill TA. Predictive value for coeliac disease of antibodies to gliadin, endomysium, and jejunum in patients attending for jejunal biopsy. BMJ. 1991 Nov 9;303(6811):1163-1165. PubMed 1747612

Collection Details:

Collection Instructions:

Red-top tube or gel-barrier tube.

Specimen should be free of bacterial contamination, hemolysis, and lipemia.

Room temperature.