9p21 CVD Risk Genotype Test (885)

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Category:

CPT Code:

81479

Test Type: Whole Blood Kit Based
Stability Time:

Stability

Refrigerated: 14 days

Reference Range:
  • rs10757278
    • Optimal
      • Genotype A/A
    • Borderline
      • Genotype A/G
    • High Risk
      • Genotype G/G
  • rs1333049
    • Optimal
      • Genotype G/G
    • Borderline
      • Genotype C/G
    • High Risk
      • Genotype C/C

Overview:

This test identifies individuals who may be at an increased risk of premature CVD which allows for risk reclassification and more aggressive management of modifiable risk factors. The 9p21 gene locus is on chromosome 9. Two 9p21 variants rs10757278 and rs1333049, found in about 40% of the population, have about a 1.5-2.0 fold increased risk of cardiovascular disease versus non-carriers in population studies. Reference: McPherson R, Pertsemilidis A, Kavaslar N, et al. A common allele on chromosome 9 associated with coronary heart disease. Science. 2007;316:1488-1491.

  • rs10757278
    • Normal CVD Risk
      • Genotype A/A
    • 1.5-Fold Increased CVD Risk
      • Genotype A/G
    • 2.0-Fold Increased CVD Risk
      • Genotype G/G
  • rs1333049
    • Normal CVD Risk
      • Genotype G/G
    • 1.5-Fold Increased CVD Risk
      • Genotype C/G
    • 2.0-Fold Increased CVD Risk
      • Genotype C/C

Methodology - Real-time polymerase chain reaction (PCR)

Collection Details:

Collection Instructions:

Preferred Specimen

1.0 mL whole blood collected in EDTA (Lavender Top)

Transport Temperature

Refrigerated (ship on frozen cold packs)